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Updated: Jan 24, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
Scalp biopsy identifies systemic amyloidosis presenting as isolated telogen effluvium: A case report
Rory A Sutherland1, Richard I Crawford2,3,4
1Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Abstract:
AL amyloidosis is a complication of B-cell dyscrasias and multiple myeloma, manifest as deposition of antibody fragments in many different organs, including the skin. We describe a rare case of this systemic disease which presented with isolated scalp alopecia. Further investigation led to the diagnosis of an occult plasma-cell dyscrasia, showing the benefit of including systemic amyloidosis in the differential diagnosis of alopecia. The biopsy finding of cutaneous amyloidosis should prompt further workup to exclude an underlying pathology.
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