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Neurocircuit Assays for Seizures in Epilepsy Mutants of Drosophila
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Poststroke seizure: optimising its management.

Michael Y Xu1

  • 1Department of Neurology, OSF Illinois Neurological Institute, University of Illinois College of Medicine, Peoria, Illinois, USA.

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|May 21, 2019
PubMed
Summary
This summary is machine-generated.

Poststroke seizure (PSS) is a common stroke complication lacking clear management guidelines. Recent research offers insights into PSS risk factors and optimal antiepileptic drug selection for improved patient care.

Keywords:
acute strokeantiepileptic drugselectroencephalographyseizures

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Area of Science:

  • Neurology
  • Epileptology
  • Stroke Medicine

Background:

  • Poststroke seizure (PSS) is a frequent and significant complication following stroke.
  • It is categorized into early and late seizures based on onset time relative to the stroke event.
  • Stroke contributes significantly to adult epilepsy, particularly in older individuals.

Purpose of the Study:

  • To review recent advancements in poststroke seizure (PSS) research.
  • To focus on critical clinical practice issues in PSS management.
  • To provide clinicians with an updated understanding for optimizing PSS care.

Main Methods:

  • Literature review of recent studies on poststroke seizure (PSS).
  • Analysis of risk factors, diagnostic tools, and treatment strategies for PSS.
  • Evaluation of antiepileptic drug (AED) efficacy and tolerability in PSS.

Main Results:

  • Two peaks of PSS occurrence are observed: the first day and 6-12 months post-stroke.
  • Risk factors include hemorrhagic stroke, cortical involvement, neurological deficit severity, younger age, family history, and genetic factors.
  • Continuous electroencephalogram (cEEG) aids in detecting subtle seizure activity, especially non-convulsive seizures.
  • No significant difference in efficacy among most antiepileptic drugs (AEDs) for PSS; levetiracetam and lamotrigine show good tolerability.

Conclusions:

  • Despite its prevalence, clinical guidelines for poststroke seizure (PSS) management remain limited.
  • Levetiracetam and lamotrigine are highlighted as well-tolerated AEDs for PSS.
  • Further research is needed to refine PSS management strategies and establish clear clinical guidelines.