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Updated: Jan 24, 2026

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis
Hong Zhu1, Arben Santo2, Zhenquan Jia3,4,5
1Department of Physiology and Pathophysiology, Campbell University Medical School, Buies Creek, NC 27506, USA.
Abstract:
While it is well known that bacterial infection is the predominant cause of sepsis, the molecular pathophysiology of this clinical syndrome remains ill-defined. In this Research Highlights article, we discuss the recent research findings regarding a protective role for glutathione peroxidase-4 (GPx4) in bacterial infection and polymicrobial sepsis via modulating ferroptosis and pyroptosis, two novel modes of regulated cell death. It is suggested that GPx4, being a requisite gateway to both ferroptosis and pyroptosis, may serve as a critical molecular target for developing effective drugs for controlling infection and sepsis.
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