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Updated: Jan 24, 2026
07:11
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
3.1K
Ring-opening cyclization of spirocyclopropanes with stabilized sulfonium ylides for the construction of a chromane
Hisanori Nambu1, Yuta Onuki1, Naoki Ono1
1Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan. nambu@pha.u-toyama.ac.jp yakura@pha.u-toyama.ac.jp.
Chemical Communications (Cambridge, England)
|May 21, 2019
Abstract:
Regioselective ring-opening cyclization of cyclohexane-1,3-dione-2-spirocyclopropanes with stabilized sulfonium ylides provided 2,3-trans-disubstituted 2,3,4,6,7,8-hexahydro-5H-1-benzopyran-5-ones in high yields without the formation of any isomers. The obtained product was readily converted into highly substituted chromane.
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