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Updated: Jan 24, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
[Effects of Aging on Endothelium-dependent Vasodilation of Human Artery]
Qi-Yong Li1, Min-Jia Zhu2, Li Chen2
1Department of Cardiology, Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital, Chengdu 610072, China.
Objective:
To determine the effects of aging on endothelium-dependent vasodilation of human artery.
Methods:
Vessel tension changes induced by acetylcholine (ACh) and endothelial-derived hyperpolarizing factor (EDHF) on gastroepiploic artery rings were recorded in 15 patients with stomach cancer aged between 51 and 83 years. The mRNA expressions of endothelial nitric oxide synthase (eNOS), cyclooxygenase (COX), cystathionineγ lyase (CSE) and the C-type natriuretic peptide (CNP) in the artery vessels were detected by qRT-PCR.
Results:
Both endothelium-dependent and EDHF induced vasodilation decreased with age (P<0.05). The mRNA expressions of eNOS, CSE and CNP also decreased with age (P<0.05), except COX.
Conclusion:
Aging could impair the function of endothelium-dependent vasodilation and EDHF-induced vasodialtion of human artery, possibly due to decreased NO, H2S and CNP in artery.
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