Related Experiment Video
Updated: Jan 24, 2026

Optogenetic Functional MRI
Published on: April 19, 2016
[Altered Functional Connectivity in Patients with Transient Ischemic Attack by Resting-state Functional MRI]
Jian Guo1, Shu-Hui Cui1, Yi-Jia Guo1
1Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To investigate longitudinal changes in functional connectivity during resting-state in patients with transient ischemic attack (TIA).
Methods:
35 patients first suffering TIA in the right hemisphere were recruited, with 35 healthy volunteers were recruited as control. At 1 week and 3 months after TIA attack, functional magnetic resonance imaging (fMRI) scans were performed, then resting-state functional connectivity was assessed and compared with that of healthy subjects. Right inferior prefrontal cortex (iPFC) and its mirror region was used as region of interest (ROI) in this analysis.
Results:
Compared with controls, higher functional connectivity with the left cerebellum, right superior temporal gyrus (STG) and insula, and lower functional connectivity with the right middle frontal gyrus (MFG) was demonstrated in patients at 1 week after TIA; while decreased functional connectivity in right STG, left insula and bilateral thalamus was shown in patients at 3 month after TIA. Correlation analysis found that functional connectivity of right iPFC with the cerebellum and insula was positively correlated with 2-back reaction time at 1 week after TIA.
Conclusion:
Although the nervous system signs of TIA can be quickly recovered, abnormal activation of working memory-related brain regions will occur for a long time.
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