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Evaluating arcuate fasciculus laterality measurements across dataset and tractography pipelines
Jonathan S Bain1, Jason D Yeatman2, Roey Schurr1
1The Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Human Brain Mapping
|May 21, 2019
Summary
Tractography methods significantly influence the detection of arcuate fasciculi asymmetry, a white-matter pathway crucial for language. Careful selection of algorithms and constraints is essential for reliable arcuate laterality assessment.
Area of Science:
- Neuroimaging
- Neuroanatomy
- Diffusion MRI
Background:
- The arcuate fasciculi are white-matter tracts connecting frontal and temporal lobes, vital for the brain's language network.
- Left-lateralization of the arcuate fasciculi is hypothesized, aligning with the dominant hemisphere for language processing.
- Previous in vivo studies using diffusion MRI tractography have shown inconsistent findings regarding arcuate fasciculi asymmetry.
Purpose of the Study:
- To investigate how different diffusion MRI tractography algorithms and methodological constraints affect estimates of arcuate fasciculi laterality.
- To assess the impact of tractography choices on both macrostructural and microstructural measures of arcuate fasciculi asymmetry.
- To determine the reliability of arcuate fasciculi asymmetry detection based on the chosen analysis pipeline.
Main Methods:
- Employed three tractography methods: deterministic, probabilistic, and LiFE (Local Illumination Field Estimation).
- Analyzed two independent diffusion MRI datasets to identify the arcuate fasciculi.
- Compared whole-brain tractograms with arcuate fasciculi constrained by anatomical cortical connections.
- Evaluated macrostructure laterality and microstructure properties (fractional anisotropy, R1).
Main Results:
- Tractography algorithm choice significantly impacted estimates of arcuate fasciculi laterality.
- Implementing anatomical cortical constraints on streamlines substantially altered laterality findings.
- Both macrostructural and microstructural indices of arcuate fasciculi laterality were sensitive to the tractography pipeline.
Conclusions:
- The choice of tractography pipeline critically influences the assessment of arcuate fasciculi laterality.
- Methodological decisions in diffusion MRI analysis affect the reliability of detecting white-matter pathway asymmetry.
- Future research must carefully consider and report tractography methods for consistent arcuate fasciculi laterality findings.
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