Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphological study of autologous rosettes (A-RFC).

B Nabarra, J Charreire

    Scandinavian Journal of Immunology
    |January 1, 1979
    PubMed
    Summary

    Autologous rosette forming cells (A-RFC) are primarily large lymphoid cells with immature nuclei. These findings suggest A-RFC may represent an immature T cell population.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Experimental autoimmune thyroiditis induced by recombinant interferon-γ.

    Immunology today·2014
    Same author

    Possible target antigens in autoimmune endocrine disease.

    Immunology today·2014
    Same author

    Ultrastructural study of the FVB/N mouse thymus: presence of an immature epithelial cell in the medulla and premature involution.

    Developmental and comparative immunology·2001
    Same author

    Thrombotic microangiopathies: renal and extrarenal lesions.

    Advances in nephrology from the Necker Hospital·2000
    Same author

    Apoptosis in parathyroid hyperplasia of patients with primary or secondary uremic hyperparathyroidism.

    Kidney international·2000
    Same author

    Induction of experimental autoimmune thyroiditis by heat-denatured porcine thyroglobulin: a Tc1-mediated disease.

    European journal of immunology·1999

    Area of Science:

    • Immunology
    • Cell Biology
    • Microscopy

    Background:

    • Autologous rosette forming cells (A-RFC) are involved in immune responses.
    • Understanding A-RFC morphology is crucial for characterizing T cell development.

    Purpose of the Study:

    • To investigate the morphology of autologous rosette forming cells (A-RFC).
    • To determine the cellular composition and characteristics of A-RFC.

    Main Methods:

    • Light and electron microscopy were employed to study A-RFC morphology.
    • Micromanipulation was used to isolate A-RFC for detailed analysis.
    • A-RFC were obtained from thymectomized mice, nude mice, and regenerating neonatal thymus grafts.

    Main Results:

    • Light microscopy revealed 76% of A-RFC were lymphoid cells, with 48% being large lymphocytes.
    • Electron microscopy confirmed 74% of isolated A-RFC were large lymphoid cells with immature nuclei.
    • The observed morphology aligns with previous data suggesting A-RFC are an immature T cell class.

    Conclusions:

    • Autologous rosette forming cells (A-RFC) are predominantly large lymphoid cells with immature nuclear features.
    • These findings support the hypothesis that A-RFC represent an immature T cell subset.
    • Further research into A-RFC could elucidate early T cell differentiation pathways.

    Related Experiment Videos