Intimal Hyperplasia After Aneurysm Treatment by Flow Diversion
Sergey Sindeev1, Sascha Prothmann2, Sergey Frolov1
1Department of Biomedical Engineering, Tambov State Technical University, Tambov, Russia.
World Neurosurgery
|May 21, 2019
Summary
Incomplete expansion of flow diverter stents can lead to high wall shear stress and intimal hyperplasia. This study used simulations to investigate hemodynamic changes from imperfect stent deployment in intracranial aneurysms.
Area of Science:
- Biomedical engineering
- Medical imaging
- Computational fluid dynamics
Background:
- Flow diverter stents are crucial for treating complex intracranial aneurysms.
- Incomplete wall apposition is a significant complication following flow diverter placement.
- This study investigates hemodynamic alterations caused by incomplete flow diverter expansion.
Observation:
- A patient-specific virtual model was used to simulate blood flow.
- Physiologically relevant conditions and clinical data informed the simulations.
- The impact of incomplete flow diverter expansion was analyzed.
Findings:
- Incomplete proximal stent expansion minimally affected intra-aneurysmal blood flow.
- High wall shear stress occurred near the incompletely expanded stent region.
- This high shear stress correlated with observed intimal hyperplasia, matching clinical outcomes.
Implications:
- Results aid in planning treatments for complex cases with potential for incomplete expansion.
- Further research is needed to guide antiplatelet therapy and interventions for improved apposition.
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