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Ivabradine and metoprolol in fixed dose combination: When, why and how to use it

V Katsi1, G Skalis2, M S Kallistratos3

  • 1Cardiology Department, Hippokration Hospital, Athens, Greece.

Pharmacological Research
|May 21, 2019
PubMed

Insights

Heart rate is a key factor in heart disease. While beta-blockers are common, new research suggests ivabradine added to beta-blockers offers a better therapeutic option for coronary artery disease and heart failure.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Heart rate is a significant factor in coronary artery disease (CAD) and heart failure.
  • While epidemiological studies suggest a pathogenetic role for heart rate, clinical trials have yielded limited strong evidence.
  • Beta-blockers are the primary drugs for heart rate control, but their effectiveness is increasingly questioned.

Purpose of the Study:

  • To evaluate the role of heart rate as a therapeutic target in cardiovascular diseases.
  • To explore the need for additional therapies beyond beta-blockers for heart rate management.
  • To investigate ivabradine as a novel therapeutic option in stable coronary disease and heart failure.

Main Methods:

  • Review of epidemiological and clinical studies on heart rate in cardiovascular diseases.
  • Analysis of recent studies assessing beta-blocker effectiveness in heart rate control and patient outcomes.
  • Examination of clinical trial data for ivabradine as an add-on therapy to beta-blockers.

Main Results:

  • Beta-blockers show insufficient effectiveness in heart rate control and their impact on outcomes is debated.
  • There is a clear need for additional therapeutic strategies for heart rate management.
  • Ivabradine, a selective heart rate inhibitor, demonstrates potential as an effective add-on therapy.

Conclusions:

  • Heart rate remains an important risk marker and therapeutic target in CAD and heart failure.
  • Ivabradine, when added to beta-blockers, represents a promising new therapeutic option for patients with stable coronary disease and heart failure.

Keywords:
Fixed dose combinationIvabradineMetoprololStable angina

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