Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Jianhui Liu1, Yuju Li2, Xiaohuan Xia3

  • 1Department of Anesthesiology, Tongji Hospital affiliated to Tongji University School of Medicine, Shanghai, China; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.

Journal of Neuroimmunology
|May 21, 2019
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Airway obstruction after anterior long-segment fusion surgery for tracheotomy:a case report].

Zhongguo gu shang = China journal of orthopaedics and traumatology·2021
Same author

All-inorganic perovskite quantum dots-based electrospun polyacrylonitrile fiber for ultra-sensitive trace-recording.

Nanotechnology·2021
Same author

Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance.

Experimental hematology·2021
Same author

FERMT3 mediates cigarette smoke-induced epithelial-mesenchymal transition through Wnt/β-catenin signaling.

Respiratory research·2021
Same author

Enhanced effect of biochar on leaching vanadium and copper from stone coal tailings by Thiobacillus ferrooxidans.

Environmental science and pollution research international·2021
Same author

Mitochondria-targeted Pt(IV) prodrugs conjugated with an aggregation-induced emission luminogen against breast cancer cells by dual modulation of apoptosis and autophagy inhibition.

Journal of inorganic biochemistry·2021
This summary is machine-generated.

Propofol, an anesthetic, reduces inflammation in immune-activated microglia by lowering extracellular vesicles (EVs). Inhibiting EV release appears key to propofol's neuroprotective and anti-inflammatory actions.

Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Propofol is a widely used anesthetic agent.
  • Microglia play crucial roles in neuroinflammation and neuroprotection.
  • Extracellular vesicles (EVs) are implicated in intercellular communication during inflammation.

Purpose of the Study:

  • To investigate the anti-inflammatory effects of propofol on microglia.
  • To determine the role of extracellular vesicles (EVs) in propofol's immunomodulatory actions.
  • To elucidate the novel molecular mechanisms underlying propofol's neuroprotective effects.

Main Methods:

  • Treatment of immune-activated microglia with propofol.
  • Quantification of extracellular vesicle (EV) levels.
  • Collection and application of EVs to assess functional effects.
Keywords:
AnestheticsExtracellular vesiclesMicrogliaNeuroinflammationNeurotoxicityPropofol

Related Experiment Videos

  • Evaluation of propofol-mediated anti-inflammatory and neuroprotective effects.

    • Main Results:

    • Propofol treatment significantly reduced extracellular vesicle (EV) levels in immune-activated microglia.
    • EVs isolated from immune-activated microglia reversed propofol's anti-inflammatory effects.
    • EVs from propofol-treated microglia failed to reverse propofol's neuroprotective effects.

    Conclusions:

    • Propofol exerts anti-inflammatory and neuroprotective effects on microglia partly through the inhibition of extracellular vesicle (EV) release.
    • Inhibition of EV release represents a novel molecular mechanism for propofol's immunomodulatory and neuroprotective actions.
    • These findings offer new insights into the therapeutic potential of propofol in neuroinflammatory conditions.