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External trigeminal nerve stimulation: A long term follow up study.

Laura Olivié1, Beatriz G Giraldez1, Alba Sierra-Marcos2

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|May 21, 2019
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External trigeminal nerve stimulation (eTNS) shows sustained efficacy for drug-resistant epilepsy (DRE). This noninvasive therapy offers good tolerability and a retention rate of 52% in the first year.

Keywords:
Drug-resistant epilepsy treatmentExternal trigeminal nerve stimulationNoninvasive neurostimulation

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Area of Science:

  • Neurology
  • Epilepsy Treatment
  • Noninvasive Neuromodulation

Background:

  • Drug-resistant epilepsy (DRE) poses significant challenges in patient management.
  • External trigeminal nerve stimulation (eTNS) is an emerging noninvasive therapeutic option for DRE.

Purpose of the Study:

  • To evaluate the long-term outcomes of eTNS in patients with DRE.
  • To assess the efficacy, retention rates, and tolerability of eTNS over a 48-month period.

Main Methods:

  • A retrospective observational study was conducted on 17 patients with DRE receiving eTNS.
  • Seizure frequency was compared before and at 6, 12, 24, 36, and 48 months post-treatment.
  • Responder rates, retention rates, and tolerability were analyzed.

Main Results:

  • Responder rates at 6 and 12 months were 35%, decreasing to 14% at 48 months.
  • Retention rates were 88% at 6 months, declining to 28.5% at 48 months.
  • No serious adverse events were reported; four patients noted improved sleep and mood.

Conclusions:

  • eTNS demonstrates comparable effectiveness to other advanced epilepsy treatments.
  • The therapy exhibits excellent tolerability with only minor side effects in a few patients.
  • Long-term retention rates suggest sustained benefit for a subset of DRE patients.