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Related Concept Videos

Self-Presentation: Self-Monitoring and Self-Handicapping02:05

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People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
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Holter Monitor: 24-Hour Monitoring01:23

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Holter monitoring is a continuous electrocardiography (ECG) recording that tracks the heart's electrical activity over an extended period, generally 24 to 48 hours. This noninvasive diagnostic tool detects irregular heart rhythms that may not be captured during a standard ECG performed in a clinical setting.DeviceThe Holter monitor is a portable, small device connected to several electrodes on the patient's chest. These electrodes detect the heart's electrical signals and transmit them to the...
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Therapeutic Drug Monitoring: Affecting Factors01:29

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Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Strategies of Self-Presentation III: Self-Monitoring01:24

Strategies of Self-Presentation III: Self-Monitoring

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Self-monitoring is a central construct in understanding individual differences in self-presentation strategies across social contexts. It refers to how individuals observe, regulate, and control their expressive behavior and self-presentation following situational cues. Self-monitoring reflects a person's sensitivity to social appropriateness and willingness to adapt behavior to fit varying interpersonal demands.High vs. Low Self-Monitoring IndividualsIndividuals high in self-monitoring are...
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Therapeutic Drug Monitoring: Overview and Classification01:16

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...
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Errors occurring during blood pressure monitoring01:25

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Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
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Multielectrode Array Recordings of the Vomeronasal Epithelium
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Ultracompact Multielectrode Array for Neurological Monitoring.

Ming-Yuan Cheng1, Ramona B Damalerio2, Weiguo Chen3

  • 1Institute of Microelectronics, Agency for Science, Technology and Research, Singapore 138634, Singapore. chengmyn@gmail.com.

Sensors (Basel, Switzerland)
|May 22, 2019
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel 3D multielectrode probe array for brain-machine interfaces. This advanced neural device enables precise monitoring of neural activity, offering potential for neurorehabilitation and communication in patients with paralysis or limb loss.

Keywords:
biopackaginglead transfermicroelectromechanical systemsneural probe array microassembly

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Brain-machine interface (BMI) technology holds promise for restoring function in individuals with paralysis, spinal cord injury, or amputated limbs.
  • Effective neural interfaces are crucial for reliable communication and neurorehabilitation through BMIs.

Purpose of the Study:

  • To develop and characterize a 32-channel three-dimensional (3D) multielectrode probe array for advanced BMI neural interface systems.
  • To ensure the device minimizes brain trauma and demonstrates robust neural signal recording capabilities.

Main Methods:

  • A novel microassembly technique involving lead transfer was employed for orthogonal assembly of the 3D probe array, preventing misalignment.
  • Standard microassembly and biopackaging processes were used, with a maximum device profile of 0.50 mm above the pia mater.
  • Benchtop electrical impedance tests and in vitro cytotoxicity assessments were performed.

Main Results:

  • The 3D multielectrode probe array demonstrated an average impedance of approximately 0.55 MΩ at 1 KHz.
  • In vitro tests confirmed the biocompatibility of the neural device.
  • In vivo implantation in rats successfully recorded local field potentials and spike signals.

Conclusions:

  • The developed 3D multielectrode probe array is a viable neural interface for BMI applications.
  • The novel microassembly technique ensures precise construction and reliable performance.
  • The device shows potential for future neuroprosthetics and therapeutic interventions.