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Safety and efficacy of bone marrow-derived cells therapy on cardiomyopathy: a meta-analysis

Chao Wang1, Jingzhao Li2, Boya Zhang2

  • 1Department of Cardiology, Tianjin Nankai Hospital, No. 6 Changjiang Road, Nankai District, Tianjin, China. chaowangbnm@yeah.net.

Stem Cell Research & Therapy
|May 22, 2019
PubMed
Abstract

Insights

Bone marrow-derived cells (BMCs) safely improve heart function and quality of life in cardiomyopathy patients. This meta-analysis confirms BMC therapy enhances left ventricular ejection fraction and reduces mortality, offering a promising treatment option.

Area of Science:

  • Regenerative Medicine
  • Cardiology
  • Cell Therapy

Background:

  • Clinical utility of bone marrow-derived cells (BMCs) for cardiomyopathy (CMP) remains controversial.
  • Existing data requires synthesis to ascertain the efficacy of BMC therapy for CMP.

Purpose of the Study:

  • To conduct a meta-analysis synthesizing available data on the clinical utility of BMCs for CMP.
  • To evaluate the safety and effectiveness of BMC treatment in patients with cardiomyopathy.

Main Methods:

  • Systematic search identified 20 studies with 1418 patients.
  • Random-effects model used to estimate weighted mean differences for key clinical outcomes.
  • Analysis included left ventricular ejection fraction (LVEF), volumes, functional capacity, and adverse events.

Main Results:

  • BMC therapy significantly improved LVEF (3.72%), 6-min walk distance, and NYHA functional class, while reducing LVESV.
  • Treatment also reduced mortality rates and improved quality of life.
  • No significant differences in LVEDV, MACE, or rehospitalization, though trends favored BMCs. Intracoronary infusion, BMSC, and higher cell doses showed greater LVEF improvement.

Conclusions:

  • BMC treatment for CMP is safe, feasible, and associated with persistent improvements in cardiac function, remodeling, and survival.
  • Intracoronary infusion of high-dose bone marrow-stimulating cells (BMSC) may be a superior therapeutic strategy.
  • Further research is warranted to validate these findings.
Keywords:
Bone marrow cellsCardiomyopathyVentricular functionVentricular remodeling

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