Related Experiment Video

Updated: Jan 24, 2026

Analysis of Coronary Vessels in Cleared Embryonic Hearts
08:25

Analysis of Coronary Vessels in Cleared Embryonic Hearts

Published on: December 7, 2016

8.6K

[Biological function of intercellular adhesion molecule-1 gene in coronary heart disease and its mediated primary

Ruiya Su1

  • 1Department of Cardiology, the First Affiliated Hospital of Nanyang Medical College, Nanyang 473000, Henan, China. Corresponding author: Su Ruiya,

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
|May 22, 2019
PubMed

Insights

Intercellular adhesion molecule-1 (ICAM-1) is significantly elevated in coronary heart disease (CHD) patients, indicating its role in disease development. This study establishes an ICAM-1 mediated regulatory network, highlighting its potential as a therapeutic target for CHD.

Area of Science:

  • Molecular Biology and Genetics
  • Cardiovascular Research
  • Immunology

Background:

  • Coronary heart disease (CHD) is a significant global health concern.
  • Intercellular adhesion molecule-1 (ICAM-1) is implicated in inflammatory processes.
  • Understanding ICAM-1's role in CHD pathogenesis is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the biological function of the ICAM-1 gene in coronary heart disease (CHD).
  • To construct a primary regulatory network mediated by the ICAM-1 gene in CHD.
  • To analyze the association between ICAM-1 gene expression and CHD.

Main Methods:

  • Systematic literature search of multiple databases (Wanfang, CNKI, VIP, Google Scholar, PubMed) from 2006-2018.
  • Meta-analysis comparing ICAM-1 levels in CHD patients versus healthy controls.
  • Gene Ontology (GO) and KEGG Pathway analysis for functional and pathway annotation of ICAM-1.

Main Results:

  • Meta-analysis of 8 studies revealed significantly higher ICAM-1 levels in CHD patients (MD = 15.29, P < 0.00001).
  • GO analysis indicated ICAM-1's involvement in receptor activity, protein binding, and leukocyte adhesion/migration.
  • A regulatory network identified ICAM-1 expression in endothelial cells, promoting leukocyte proliferation and CHD development.

Conclusions:

  • ICAM-1 plays a regulatory role in CHD occurrence and progression, primarily through leukocyte-related biological processes.
  • The established ICAM-1 mediated regulatory network provides a foundation for further research into ICAM-1's specific role in CHD.
  • Targeting ICAM-1 and related genes may offer novel therapeutic strategies for coronary heart disease.
Abstract

More Related Videos

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

8.1K
CRISPR-mediated Loss of Function Analysis in Cerebellar Granule Cells Using In Utero Electroporation-based Gene Transfer09:39

CRISPR-mediated Loss of Function Analysis in Cerebellar Granule Cells Using In Utero Electroporation-based Gene Transfer

Published on: June 9, 2018

10.3K

Related Concept Videos

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
9.2K
Primary and Secondary Growth in Roots and Shoots03:02

Primary and Secondary Growth in Roots and Shoots

Vascular plants, which account for over 90% of the Earth’s vegetation, all undergo primary growth—which lengthens roots and shoots. Many land plants, notably woody plants, also undergo secondary growth—which thickens roots and shoots.
60.3K
Primary and Secondary Reinforcers01:23

Primary and Secondary Reinforcers

In psychology, reinforcement is a key concept in behavior modification. B.F. Skinner demonstrated this with his experiments involving rats in what is known as a Skinner box. The rats learned to press a lever to receive food, a primary reinforcer that fulfilled their innate need for nourishment.
Effective reinforcers for humans vary depending on the individual and the context. Primary reinforcers, such as food, water, sleep, shelter, and pleasure, have inherent value and satisfy basic biological...
902
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.6K
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
4.3K
Secondary Active Transport01:55

Secondary Active Transport

One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme “pump” embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
137.4K