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Updated: Jan 24, 2026
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Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
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Conserved signaling pathways genetically associated with longevity across the species
Abdul Haseeb Khan1, Zhiwen Zou2, Yang Xiang1
1Human population genetics, Human Aging Research Institute (HARI), Nanchang University, Xuefu Rd 999, Honggutan New District, Nanchang, Jiangxi Province 330031, China; School of Life Science, Nanchang University, Xuefu Rd 999, Honggutan New District, Nanchang, Jiangxi Province 330031, China.
Summary
Investigating longevity genes across diverse organisms reveals conserved genetic pathways crucial for healthy aging. Understanding these genetic factors offers insights into preventing age-related diseases and promoting longer, healthier lives.
Area of Science:
- Gerontology and Genetics
- Comparative Biology
- Molecular Biology
Background:
- Advanced age is a primary risk factor for mortality and debilitating diseases like cardiovascular conditions, dementia, and cancers.
- Healthy longevity presents a model for successful aging, necessitating research into its underlying genetic mechanisms.
- Genetic factors play a significant role in determining longevity, as evidenced by studies in model organisms.
Purpose of the Study:
- To review the utilization of various model organisms in identifying genetic determinants of longevity.
- To discuss the genetic contributions of conserved longevity pathways to aging and healthspan.
- To explore the genetic basis of healthy aging and its implications for disease prevention.
Main Methods:
- Comprehensive literature review of studies employing model organisms (yeast, ciliate, nematode, arthropod, fish, rodent, primate) and humans.
- Analysis of identified longevity-associated genes and their functional roles.
- Examination of conserved signaling pathways implicated in aging and lifespan regulation.
Main Results:
- Model organisms have been instrumental in uncovering genetic factors influencing longevity.
- Conserved longevity pathways, including the adrenergic system, AMPK, insulin/IGF-1, and mTOR signaling, are critical for aging processes.
- Genetic components significantly contribute to lifespan determination across species.
Conclusions:
- Identifying longevity genes and pathways provides a unique approach to understanding aging and healthspan.
- Genetic research in model organisms offers valuable insights into human aging and age-related diseases.
- Targeting conserved longevity pathways may hold therapeutic potential for promoting healthy aging.
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