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Childhood lead poisoning in Gaza Strip, the Palestinian Authority
Jamal M Safi1, Maged M Yassin2, Yasser Z El-Nahhal3
1Environmental Protection and Research Institute, Gaza Strip, Palestine; Faculty of Agriculture and Environment, Al-Azhar University-Gaza, Palestine.
Insights
Childhood lead poisoning is a significant health issue in Gaza Strip, with 95.7% of children near lead industries having elevated blood lead levels (BLLs). Treatment with d-penicillamine effectively reduced BLLs, highlighting the need for health education and prevention campaigns.
Area of Science:
- Environmental Health
- Pediatric Toxicology
- Public Health
Background:
- Lead poisoning poses a substantial health risk to children, particularly in industrial areas.
- Assessing blood lead levels (BLLs) is crucial for identifying and managing pediatric lead exposure.
Purpose of the Study:
- To evaluate the prevalence and impact of lead poisoning in children aged 2-6 years in the Gaza Strip.
- To assess the effectiveness of d-penicillamine in treating elevated BLLs in pediatric populations.
Main Methods:
- Collected blood samples and questionnaires from 1705 children (aged 2-6) in Gaza Strip.
- Measured blood lead levels (BLLs) using LeadCare kits, comparing children from lead processing 'hotspots' and the general population.
- Administered d-penicillamine (30 mg/kg/day for two weeks) to children with BLLs above 20 μg/dL.
Main Results:
- A significant prevalence of elevated BLLs (≥10 μg/dL) was observed, with 95.7% in hotspot areas versus 9.3% in the general population.
- The mean BLL across all children was 10.4 μg/dL, with 25.8% having BLLs ≥10 μg/dL.
- Treatment with d-penicillamine effectively reduced BLLs to acceptable levels (<10 μg/dL).
Conclusions:
- Childhood lead poisoning is a major public health concern in the Gaza Strip, strongly linked to lead industry hotspots.
- Targeted health education and treatment interventions, including d-penicillamine, are essential for mitigating lead poisoning.
- Preventive strategies are crucial to reduce the burden of lead-related illnesses in children.
Purpose:
To assess lead poisoning among a pediatric population in Gaza Strip, the Palestinian Authority.
Methods:
A total of 1705 questionnaires and blood samples were collected from children aged 2-6 years, by the finger stick capillary procedure, for the assessment of blood lead level (BLL), using the LeadCare kits. The samples were collected from children living close to lead processing units (hotspots) and far 100-500 m away (general population). Management of elevated BLL was achieved by gavage of chelating agent d-penicillamine at a dose of 30 mg kg-1 body weight/day for two weeks for children having BLL above 20 μg/dl. Data were statistically analyzed using SPSS computer program version 22.
Results:
Distribution of children in Gaza Strip by sampling process illustrated those 326 children (19.1%) living in lead processing units (hot spots) and 1379 children (80.9%) from location far away 100-500 m from host spot (general population). The mean BLL was 10.4 μg/dl. A total of 440 children (25.8%) were found to be having BLL ≥ 10 μg/dl while 1265 children (74.2%) have BLL < 10 μg/dl. BLL < 10 μg/dl was taken as a cut point due to CDC standards. The prevalence of BLL in hotspot areas in children who were exposed to lead and have BLL ≥ 10 μg/dl was 95.7% while in general population it was 9.3%. The difference between the study population was statistically significant (p < 0.01). Statistical significant differences between the study populations were found among several independent variables of risk factors such as household location and exposure sources, and occupational exposure. Gavage of d-penicillamine significantly reduced BLL to the acceptable level (BLL < 10 μg/dl).
Conclusions:
Childhood lead poisoning accounts for a substantial burden in Gaza Strip. Hotspots of lead-related industries are the high risk areas that contributing to high BLLs in children. d-Penicillamine was effective in the treatment of lead poisoning among children. Health education and treatment campaigns should be designed to minimize or prevent childhood lead poisoning in Gaza Strip.
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