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Preventive impacts of PAS-Na on the slow growth and activated inflammatory responses in Mn-exposed rats

Dong-Jie Peng1, Yu-Wen Zhang1, Zhao-Cong Li1

  • 1Department of Toxicology, School of Public Health, Guangxi Medical University, 530021, Nanning, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, China.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|May 22, 2019
PubMed
Abstract

Insights

Sodium para-aminosalicylic acid (PAS-Na) prevents manganese-induced growth retardation and inflammation in rats. This study shows PAS-Na reduces manganese levels and alleviates inflammatory responses, offering potential therapeutic benefits for manganese poisoning.

Area of Science:

  • Toxicology
  • Pharmacology

Background:

  • Sodium para-aminosalicylic acid (PAS-Na), an anti-tuberculosis drug, aids manganese elimination and improves manganese poisoning symptoms.
  • The effect of PAS-Na on manganese-induced growth retardation and inflammation remains uninvestigated.

Purpose of the Study:

  • To investigate the preventive effects of PAS-Na on growth retardation and inflammatory responses in manganese-exposed rats.

Main Methods:

  • Male Sprague Dawley rats were exposed to manganese chloride (MnCl2) or saline for 4 or 8 weeks.
  • The PAS-Na preventive group received MnCl2 and PAS-Na, while the PAS-Na control group received saline and PAS-Na.
  • Body weight, blood manganese levels, serum inflammatory factors (TNF-α, IL-1β, IL-6, PGE2), and organ coefficients were measured.

Main Results:

  • Manganese exposure suppressed growth and increased heart, liver, spleen, and kidney coefficients.
  • Blood manganese and serum inflammatory markers (IL-1β, IL-6, PGE2, TNF-α) were elevated in manganese-exposed rats.
  • PAS-Na treatment reduced blood manganese levels, spleen and liver coefficients, and significantly decreased serum IL-1β and TNF-α.

Conclusions:

  • PAS-Na demonstrates preventive effects against manganese-induced growth retardation.
  • PAS-Na effectively alleviates inflammatory responses associated with manganese exposure.
Keywords:
Inflammatory responseManganeseRetardationSodium para-aminosalicylic acid (PAS-Na)

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