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Meta-analysis of Atrial Fibrillation in Patients With Various Cardiomyopathies

Jean Jacques Noubiap1, Jean Joel Bigna2, Valirie N Agbor3

  • 1Department of Medicine, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.

The American Journal of Cardiology
|May 22, 2019
PubMed

Insights

Atrial fibrillation (AF) affects 1-2 in 10 patients with cardiomyopathy, except peripartum types. This prevalence highlights the need for integrated AF management in cardiomyopathy guidelines.

Area of Science:

  • Cardiology
  • Epidemiology
  • Internal Medicine

Background:

  • Atrial fibrillation (AF) is a significant risk factor for adverse outcomes in patients with cardiomyopathy, including thromboembolism, heart failure progression, and mortality.
  • Understanding the prevalence of AF across different types of cardiomyopathy is crucial for clinical management and public health strategies.

Purpose of the Study:

  • To systematically review and meta-analyze the global prevalence of atrial fibrillation (AF) in patients diagnosed with various forms of cardiomyopathy.
  • To provide an updated epidemiological estimate of AF in cardiomyopathy populations.

Main Methods:

  • A comprehensive systematic review and meta-analysis of studies published in PubMed and EMBASE from inception to June 30, 2017.
  • Inclusion of 220 full-text articles representing 118,668 participants, with random-effect modeling used to estimate AF prevalence and heterogeneity.
  • Independent assessment of methodological quality for eligible papers.

Main Results:

  • The overall prevalence of AF in cardiomyopathy patients was estimated, with significant variation across subtypes.
  • Highest AF prevalence observed in dilated cardiomyopathy (24%), ischemic cardiomyopathy (20%), and hypertrophic cardiomyopathy (19%).
  • Lowest AF prevalence noted in peripartum cardiomyopathy (5%), with no significant gender difference observed.

Conclusions:

  • AF is common in most cardiomyopathy types, affecting 1-2 in 10 patients, underscoring the need for proactive management.
  • Peripartum cardiomyopathy appears to have a lower prevalence of AF compared to other forms.
  • Clinical guidelines should incorporate the management of AF across all cardiomyopathy classifications.

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