Antibacterial evaluation and mode of action study of BIMQ, a novel bacterial cell division inhibitor
Ning Sun1, Ming Li1, Senyuan Cai2
1The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, PR China.
Abstract:
The worldwide spreading of antibiotic resistant bacteria is currently an extremely serious health risk and therefore to develop new antibiotics is an urgent need. In the present study, the antibacterial activity of a new indolyl quinolinium compound and its underline mechanism were investigated. The compound shows an outstanding antibacterial activity against the tested Gram-positive bacteria. The MIC values are in the range of 1-4 μg/mL. The elongation of B. subtilis cells indicates that the compound can inhibit cell division effectively. In addition, the biochemical studies prove that the compound is able to disrupt FtsZ polymerization effectively through a stimulatory mechanism. Furthermore, the compound can delay the development of drug resistance mutants.
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