Related Experiment Video

Updated: Jan 24, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
07:49

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

20.9K

Time-of-Day-Dependent Trafficking and Function of Leukocyte Subsets

Robert Pick1, Wenyan He2, Chien-Sin Chen3

  • 1Walter-Brendel-Centre of Experimental Medicine, University Hospital, Ludwig-Maximilians-University Munich, BioMedical Centre, Planegg-Martinsried, Germany; These authors contributed equally to this work.

Trends in Immunology
|May 22, 2019
PubMed

Insights

Mammalian blood leukocyte counts follow a daily circadian rhythm. This study details how rhythmic expression of molecules controls leukocyte movement into tissues, offering potential therapeutic strategies.

Area of Science:

  • Immunology
  • Chronobiology
  • Cell Biology

Background:

  • Circadian rhythms influence physiological processes, including immune cell circulation.
  • Leukocyte migration is critical for immune surveillance and inflammatory responses.

Purpose of the Study:

  • To summarize recent findings on the mechanisms of circadian-controlled leukocyte migration.
  • To highlight molecular regulators of rhythmic leukocyte recruitment.
  • To explore the role of clock genes in leukocyte function and migration.

Main Methods:

  • Review of latest research findings on leukocyte migration and circadian control.
  • Analysis of molecular mechanisms involving adhesion molecules, chemokines, and receptors.
  • Comparison of immune cell rhythms in steady-state, inflammation, and disease.

Main Results:

  • Leukocyte migration into organs is under circadian control, involving specific molecules.
  • Oscillatory expression of adhesion molecules, chemokines, and receptors governs rhythmic leukocyte recruitment.
  • Clock genes are relevant for leukocyte function and migration patterns.

Conclusions:

  • Circadian regulation of leukocyte migration is mediated by rhythmic molecular interactions.
  • Understanding these rhythms offers potential for novel therapeutic interventions in immune-related conditions.
  • Immune cell rhythms differ between homeostatic and disease states.

More Related Videos

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets08:12

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

7.6K
In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints10:10

In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints

Published on: December 9, 2025

574

Related Concept Videos

Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
4.0K
The Integrated Rate Law: The Dependence of Concentration on Time02:39

The Integrated Rate Law: The Dependence of Concentration on Time

While the differential rate law relates the rate and concentrations of reactants, a second form of rate law called the integrated rate law relates concentrations of reactants and time. Integrated rate laws can be used to determine the amount of reactant or product present after a period of time or to estimate the time required for a reaction to proceed to a certain extent. For example, an integrated rate law helps determine the length of time a radioactive material must be stored for its...
41.1K
Chronopharmacokinetics: Time-Dependent Pharmacokinetics01:20

Chronopharmacokinetics: Time-Dependent Pharmacokinetics

Chronopharmacokinetics studies the temporal change in drug absorption and elimination. These changes can be cyclical or non-cyclical. Cyclical changes occur over a regular interval, while non-cyclical changes occur over a longer, irregular period.
Time-dependent pharmacokinetics refers to non-cyclical changes in drug rate processes over a period of time. It can lead to nonlinear pharmacokinetics, where the relationship between drug concentration and time is not proportional. Non-cyclical...
406
Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
5.2K
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.8K
Frequency-dependent Selection01:21

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
23.3K