Related Experiment Video
Updated: Jan 24, 2026
08:01
Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
2.2K
Paraneoplastic phenomenon in mesothelioma
Ali Bin Waqar1, Daniel Menzies2, Mared Casey3
1Respiratory Medicine, Betsi Cadwaladr University Health Board, Bodelwyddan, UK alibinwaqar@gmail.com.
Thorax
|May 22, 2019
Summary
A 71-year-old man developed breathlessness and vision problems. Investigations revealed mesothelioma and positive anti-Ma2 antibodies, indicating a paraneoplastic syndrome caused his vertical gaze palsy.
Area of Science:
- Neurology
- Oncology
- Pulmonology
Background:
- Mesothelioma is a rare cancer often associated with asbestos exposure.
- Paraneoplastic syndromes can manifest with neurological symptoms preceding cancer diagnosis.
Observation:
- A 71-year-old male presented with dyspnea and visual disturbances.
- Clinical examination revealed right-sided pleural effusion and conjugate vertical gaze palsy.
- Imaging showed pleural thickening consistent with mesothelioma.
Findings:
- Histopathological analysis confirmed mesothelioma.
- Positive anti-Ma2 antibodies were detected in serum.
- The anti-Ma2 antibody positivity indicated a paraneoplastic neurological syndrome.
Implications:
- This case highlights the importance of investigating neurological symptoms in patients with unexplained pleural effusions.
- Early detection of paraneoplastic syndromes can lead to timely mesothelioma diagnosis and treatment.
- Anti-Ma2 antibodies serve as a crucial biomarker for paraneoplastic neurological disorders associated with specific cancers.
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