Posterior cingulate cortex can be a regulatory modulator of the default mode network in task-negative state
Regina W Y Wang1,2, Wei-Li Chang3,4, Shang-Wen Chuang3,4
1Design Perceptual Awareness Lab (D:PAL), National Taiwan University of Science and Technology (Taiwan Tech), Taipei, Taiwan. wyw@mail.ntust.edu.tw.
Scientific Reports
|May 22, 2019
Summary
Electroencephalography (EEG) reveals how brain networks function differently with eyes open versus closed. Introverts exhibit stronger default mode network (DMN) connectivity, particularly in the posterior cingulate cortex (PCC) and medial prefrontal cortex (mPFC).
Area of Science:
- Neuroscience
- Brain Network Regulation
- Cognitive Electrophysiology
Background:
- Understanding brain network regulation and inter-regional interactions is crucial in neuroscience.
- Effective connectivity analysis helps elucidate the modulatory mechanisms within brain networks.
- Few studies have explored effective connectivity in task-negative modes using electroencephalography (EEG).
Purpose of the Study:
- To measure EEG effective connectivity within default mode network (DMN) regions.
- To investigate the effects of task-negative modes (eyes-open/eyes-closed) on brain connectivity.
- To examine the influence of personality traits (introversion/extroversion) on DMN connectivity.
Main Methods:
- High-density EEG experiments were conducted on 85 participants.
- Effective connectivity was measured in key DMN regions: medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), precuneus, and frontal/occipital regions.
- Analysis focused on eyes-open versus eyes-closed states and introversion versus extroversion.
Main Results:
- In the eyes-closed state, the PCC showed significantly increased effective connectivity, modulating outflow via alpha rhythms.
- The mPFC acted as a regulatory modulator in the eyes-open state, mediated by delta rhythms.
- Introverts displayed stronger co-modulations within DMN regions compared to extroverts.
Conclusions:
- Brain network connectivity, particularly within the DMN, is modulated by task-negative states (eyes-open/closed) and personality.
- The PCC and mPFC play distinct regulatory roles in different task-negative conditions, associated with specific brain rhythms.
- Personality traits, specifically introversion/extroversion, correlate with differences in DMN effective connectivity.
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