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Patient access to compounded drugs in paediatrics after discharge from a tertiary centre

Marie-Kim Héraut1, Minh-Thu Duong1, Clara Elchebly1

  • 1Pharmacy Department and Pharmacy Practice Research Unit, CHU Sainte-Justine, Montreal, Quebec.

Paediatrics & Child Health
|May 22, 2019
PubMed

Insights

Parents and young patients face numerous problems with compounded drugs, indicating a need for improved standards in drug compounding and dispensing to ensure pediatric patient safety.

Area of Science:

  • Pediatric Pharmacy
  • Drug Compounding
  • Patient Safety

Background:

  • Compounded drugs are frequently prescribed for pediatric patients.
  • Challenges exist in the procurement and administration of these specialized medications.

Purpose of the Study:

  • To identify and describe the issues encountered by pediatric patients and their parents when obtaining and using compounded medications.
  • To evaluate the safety and efficacy of compounded drug use in a young patient population.

Main Methods:

  • A prospective observational descriptive study was conducted.
  • Data collected via telephone questionnaires from families of pediatric patients (0-21 years) discharged with compounded drugs.
  • Prescriptions were compared against dispensed drugs and master formulas.

Main Results:

  • Surveyed 71 patients (median age 6.9 months) regarding 99 compounded drugs (34 oral formulations).
  • Identified 314 issues, with 252 classified as problems (9 major, 243 minor).
  • Problems had potential or real consequences for patient safety.

Conclusions:

  • A significant number of compounding-related problems were identified.
  • Current practice standards for compounded drugs are insufficient.
  • Improvements in the use and dispensation of compounded drugs are necessary to enhance patient safety.
Abstract

Keywords:
CompoundingDrug-related problemsPediatricPharmacy

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