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Cerebellar Cryptococcal Abscess in HIV-Negative Patient: A Case Report and Literature Review

Ni Putu Sriwidyani1, Ni Luh G Sagita Dewi1, I Nyoman Golden2

  • 1Anatomical Pathology Department, Faculty of Medicine Udayana University, Sanglah General Hospital, Bali, Indonesia.

Open Access Macedonian Journal of Medical Sciences
|May 22, 2019
PubMed
Abstract

Insights

Cryptococcosis, a fungal infection, is increasingly seen in immunocompetent individuals, not just those with HIV. This case highlights cryptococcal brain abscesses in an immunocompetent patient.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Neurology

Background:

  • Cryptococcus is a significant opportunistic pathogen, particularly in HIV-positive individuals.
  • While AIDS-associated cryptococcosis has declined, infections in immunocompetent hosts are rising.
  • Understanding cryptococcosis in diverse host populations is crucial.

Observation:

  • A 64-year-old male presented with severe headache and cerebellar lesions on MRI.
  • Initial imaging suggested abscess or metastatic disease.
  • HIV testing was negative, indicating an immunocompetent status.

Findings:

  • Surgical intervention revealed multiple cryptococcal abscesses.
  • Microscopic examination confirmed PAS-positive budding yeasts, characteristic of Cryptococcus.
  • This case underscores cryptococcosis in an immunocompetent individual.

Implications:

  • Cryptococcosis can occur in immunocompetent patients, challenging typical epidemiological assumptions.
  • Clinical presentation is influenced by pathogen virulence and host immune status.
  • Effective antifungal treatment is essential, with prognosis tied to underlying conditions.
Keywords:
AbscessCerebellumCryptococcosisFungalImmune-competent

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