Mild stimulation approach for In Vitro Fertilization treatment: Retrospective data from one Danish Centre
G Almind1, E Faerch1, F Lindenberg1
1Copenhagen Fertility Center, Lygten 3c, 2400 Copenhagen, Denmark.
Facts, Views & Vision in Obgyn
|May 22, 2019
Summary
Mild stimulation offers an effective and more tolerable approach to In Vitro Fertilization (IVF), achieving comparable clinical pregnancy rates (CPR) to conventional IVF. This method presents a potentially easier and more cost-effective option for patients and society.
Area of Science:
- Reproductive Medicine
- Infertility Treatment
- Assisted Reproductive Technology
Background:
- Conventional In Vitro Fertilization (IVF) protocols often involve hyperstimulation, leading to an excess of unused oocytes.
- Improvements in laboratory procedures necessitate evaluating less intensive stimulation methods.
Purpose of the Study:
- To assess the efficacy of a mild stimulation protocol for oocyte retrieval in IVF.
- To compare a short antagonist protocol using Tamoxifen and FSH with conventional IVF.
Main Methods:
- Retrospective observational study of 720 mild stimulation cycles and 8,446 conventional IVF cycles.
- Mild stimulation involved oral anti-estrogenic drugs and FSH injections to target up to four mature follicles.
- Patients with unexplained infertility were included, allocated to treatments based on request.
Main Results:
- Clinical pregnancy rate (CPR) per embryo transfer (ET) was 25% in the mild stimulation group.
- CPR in the conventional IVF control group was 23% per ET.
- The success rates were comparable between the two protocols.
Conclusions:
- Mild stimulation represents a more tolerable, simpler, and cost-effective IVF approach.
- It maintains an acceptable clinical pregnancy rate, offering a viable alternative.
- Further large-scale prospective studies are recommended to validate these findings.
Related Concept Videos
01:24In Vitro Fertilization
922
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
922
01:38Fertilization
90.3K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
90.3K
01:14Model Approaches for Pharmacokinetic Data: Compartment Models
543
Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
Two primary types of compartment models are recognized: mammillary and catenary. The more...
543
01:15Model Approaches for Pharmacokinetic Data: Physiological Models
253
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
253
00:59Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis
330
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
330
01:06Model Approaches for Pharmacokinetic Data: Distributed Parameter Models
247
Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
247