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The black background, normal contrast setting (B+N) on spectral domain-optical coherence tomography (SD-OCT) best measures subfoveal choroidal thickness (CT). Automated software also reliably assesses CT.

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Area of Science:

  • Ophthalmology
  • Medical Imaging

Background:

  • Accurate measurement of subfoveal choroidal thickness (CT) is crucial for diagnosing and monitoring various ocular conditions.
  • Spectral domain-optical coherence tomography (SD-OCT) is a key imaging modality for in vivo ocular assessment.
  • Optimizing SD-OCT settings is essential for improving the reliability of CT measurements.

Purpose of the Study:

  • To determine the optimal spectral domain-optical coherence tomography (SD-OCT) setting for measuring subfoveal choroidal thickness (CT).
  • To compare manual CT measurements with automated segmentation software results.

Main Methods:

  • Thirty patients underwent enhanced depth imaging (EDI)-OCT, acquiring 180 images across six different SD-OCT settings.
  • Subfoveal CT was manually measured by nine graders and by automated segmentation software.
  • Intraclass correlation (ICC) was assessed to evaluate measurement reliability.

Main Results:

  • The black background, normal contrast (B+N) setting yielded the highest ICC (0.64) for manual CT measurement.
  • Achromatic images demonstrated higher ICC than color images, and black backgrounds performed better than white.
  • Automated CT assessment showed a significant correlation with manual measurements (r = 0.6, P = 0.001).

Conclusions:

  • The B+N setting is recommended for manual assessment of subfoveal CT using SD-OCT.
  • Automated segmentation software presents a reliable tool for CT assessment, aiding in optimized OCT analysis.