Related Experiment Video
Updated: Jan 24, 2026
08:17
Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
Published on: September 22, 2017
20.0K
Retinal Arteriole Pulse Waveform Analysis Using a Fully-Automated Doppler Optical Coherence Tomography Flowmeter: a
Jun Sakai1, Kana J Minamide1, Syunsuke Nakamura1
1Research and Development Division, Topcon Corporation, Tokyo, Japan.
Translational Vision Science & Technology
|May 22, 2019
Summary
A new Doppler optical coherence tomography (DOCT) flowmeter shows good repeatability and reproducibility for measuring retinal arteriole pulse waveforms. This automated device may help monitor systemic circulation abnormalities.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Cardiovascular Research
Background:
- Retinal arteriole pulse waveforms provide insights into systemic circulation.
- Accurate and reproducible measurements are crucial for clinical applications.
- Existing methods may have limitations in automation and precision.
Purpose of the Study:
- To assess the repeatability and reproducibility of a novel, fully-automated Doppler optical coherence tomography (DOCT) flowmeter.
- To evaluate the measurement of retinal arteriole pulse waveforms in healthy subjects.
Main Methods:
- Twenty eyes from 20 healthy subjects were analyzed for intrasession repeatability.
- Doppler optical coherence tomography (DOCT) measurements utilized an instantaneous Doppler angle method.
- Upstroke time (UT) and resistance index (RI) were calculated; coefficients of variation (CVs) and intraclass correlation coefficients (ICCs) were determined.
- Interdevice reproducibility was assessed using two DOCT instruments on five subjects.
Main Results:
- The mean UT was 130.3 ms and the mean RI was 0.66.
- Intrasession repeatability showed high ICCs (UT: 0.87, RI: 0.78) and low CVs (UT: 6.6 ± 3.3%, RI: 4.7 ± 2.1%).
- No significant differences were found in interdevice reproducibility between the two instruments (P > 0.05).
Conclusions:
- The fully-automated DOCT flowmeter demonstrates good intrasession repeatability and interdevice reproducibility for retinal arteriole pulse waveform analysis.
- This improved DOCT system offers reliable measurements, potentially aiding in the monitoring of systemic circulation abnormalities.
More Related Videos
Related Concept Videos
01:16Arteries and Arterioles
6.4K
Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles...
6.4K
00:56Doppler Effect - I
6.2K
The Doppler effect and Doppler shift were named after the Austrian physicist and mathematician Christian Johann Doppler in 1842, who conducted experiments with both moving sources and moving observers. Consider an observer standing on a street corner, observing an ambulance with a siren sound passing by at a constant speed. The observer experiences two characteristic changes in the sound of the siren. Initially, the sound increases in loudness as the ambulance approaches and decreases in...
6.2K
01:05Doppler Effect - II
4.5K
The Doppler effect has several practical, real-world applications. For instance, meteorologists use Doppler radars to interpret weather events based on the Doppler effect. Typically, a transmitter emits radio waves at a specific frequency toward the sky from a weather station. The radio waves bounce off the clouds and precipitation and travel back to the weather station. The radio frequency of the waves reflected back to the station appears to decrease if the clouds or precipitation are moving...
4.5K
01:21Pilot and Numeric Relaying
485
Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:
485
01:07Effective Value of a Periodic Waveform
1.2K
The concept of effective value, the root mean square (RMS) value, is crucial in understanding electrical circuits and power delivery. This idea emerges from the necessity to measure the effectiveness of a voltage or current source in supplying power to a resistive load.
The effective value of a periodic current represents the direct current (DC) that conveys the same average power to a resistor as the periodic current itself. This concept is crucial when assessing AC circuits. To determine the...
The effective value of a periodic current represents the direct current (DC) that conveys the same average power to a resistor as the periodic current itself. This concept is crucial when assessing AC circuits. To determine the...
1.2K
01:16Pulse
2.0K
When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
The pulse serves as a clinical...
2.0K