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Long Noncoding RNA in Preeclampsia: Transcriptional Noise or Innovative Indicators?

Xiuhua Yang1, Tao Meng1

  • 1Department of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning, China.

Biomed Research International
|May 22, 2019
PubMed

Insights

Long noncoding RNAs (lncRNAs) show promise as biomarkers for preeclampsia (PE), an obstetric condition. These molecules influence PE development through various biological pathways, aiding in prediction and diagnosis.

Area of Science:

  • Obstetrics and Gynecology
  • Molecular Biology
  • Genetics

Background:

  • Preeclampsia (PE) is a serious pregnancy complication characterized by hypertension and proteinuria after 20 weeks.
  • PE poses significant risks to maternal and fetal well-being.
  • Long noncoding RNAs (lncRNAs), once dismissed as transcriptional noise, are emerging as potential diagnostic and prognostic indicators.

Purpose of the Study:

  • To review and synthesize recent research on the role of lncRNAs in preeclampsia.
  • To elucidate the mechanisms by which lncRNAs contribute to PE pathogenesis.
  • To explore the potential of lncRNAs as predictive and diagnostic markers for PE.

Main Methods:

  • Literature review of studies investigating lncRNAs and preeclampsia.
  • Analysis of data on lncRNA involvement in trophoblast function, immune regulation, epigenetics, decidualization, and metabolism.
  • Synthesis of findings to understand lncRNA mechanisms in PE.

Main Results:

  • lncRNAs are implicated in the occurrence and progression of PE.
  • They impact PE through modulation of trophoblast biological functions.
  • lncRNAs influence immune responses, epigenetic modifications, decidualization, and energy metabolism in the context of PE.

Conclusions:

  • lncRNAs play a crucial role in the pathogenesis of preeclampsia.
  • Understanding lncRNA mechanisms offers insights into PE development.
  • lncRNAs hold potential as novel targets for PE prediction and diagnosis.

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