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Related Experiment Video

Updated: Jan 24, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
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Statin therapy increases lipoprotein(a) levels.

Sotirios Tsimikas1, Philip L S M Gordts2,3, Chelsea Nora2,3

  • 1Vascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiovascular Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0682, USA.

European Heart Journal
|May 22, 2019
PubMed
Summary

Statins significantly increase lipoprotein(a) [Lp(a)] levels in patients. Further research is needed to understand the impact of these Lp(a) elevations on residual cardiovascular risk.

Keywords:
Aortic stenosisAssayCardiovascular diseaseLipoprotein(a)

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Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Biochemistry

Background:

  • Elevated Lipoprotein(a) [Lp(a)] affects 20-30% of the population.
  • Lp(a) is an independent risk factor for cardiovascular disease.
  • Understanding factors influencing Lp(a) levels is crucial for risk management.

Purpose of the Study:

  • To evaluate the effect of statin therapy on plasma Lp(a) levels.
  • To compare Lp(a) changes between statin and placebo groups.
  • To compare Lp(a) changes between different statins.

Main Methods:

  • Subject-level meta-analysis of six randomized controlled trials.
  • Inclusion of 5256 patients (3885 on statin, 1371 on placebo).
  • Analysis of pre- and on-treatment Lp(a) levels (4-104 weeks) using a validated assay.

Main Results:

  • Statins significantly increased Lp(a) levels compared to placebo (ratio of geometric means 1.11; P < 0.0001).
  • Mean Lp(a) increase ranged from 8.5% to 19.6% with statins versus -0.4% to -2.3% with placebo.
  • Atorvastatin showed a higher increase in Lp(a) compared to pravastatin (ratio 1.09; P < 0.0001).
  • In vitro study showed atorvastatin increased LPA mRNA and apolipoprotein(a) protein expression.

Conclusions:

  • Statin therapy is associated with a significant increase in plasma Lp(a) levels.
  • The observed elevations in Lp(a) warrant further investigation regarding residual cardiovascular risk.
  • Clinical implications of statin-induced Lp(a) changes require additional study.