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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Homocysteine, rather than age of onset, is a better predictor for cognitive function in older adults with bipolar

Pao-Huan Chen1,2, Hsing-Cheng Liu2,3, Mong-Liang Lu2,4

  • 1Department of Psychiatry, Taipei Medical University Hospital, Taipei, Taiwan.

International Journal of Geriatric Psychiatry
|May 22, 2019
PubMed

Insights

Late-onset bipolar disorder (LOBD) in older adults shows no cognitive decline compared to early-onset bipolar disorder (EOBD). However, elevated homocysteine levels are linked to poorer cognitive function in this population.

Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Bipolar disorder in older adults may be linked to cognitive impairments, potentially influenced by vascular factors.
  • Distinguishing between late-onset bipolar disorder (LOBD) and early-onset bipolar disorder (EOBD) is crucial for understanding cognitive trajectories.

Purpose of the Study:

  • To compare cognitive function between older individuals with LOBD and EOBD.
  • To investigate the role of vascular risk burden and biochemical markers in cognitive performance.

Main Methods:

  • 95 outpatients over 55 with bipolar I disorder were assessed.
  • Cognitive function was evaluated using a comprehensive test battery.
  • Vascular risk factors, cardiovascular risk scores, and serum biomarkers (homocysteine, B12, folate, T3) were assessed.

Main Results:

  • No significant cognitive differences were found between LOBD and EOBD groups after adjusting for confounders.
  • Higher serum homocysteine levels were negatively associated with cognitive performance in attention, psychomotor speed, verbal memory, and executive function.

Conclusions:

  • Late-onset bipolar disorder is not associated with greater cognitive dysfunction compared to early-onset bipolar disorder in older adults.
  • Elevated serum homocysteine levels correlate with worse cognitive function in older bipolar disorder patients, warranting clinical attention.
Abstract

Keywords:
Framingham risk scoreage of onsethomocysteineneurocognitive performanceolder-age bipolar disorder

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