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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
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Molecularly Imprinted Materials for Selective Biological Recognition.

Nan Zhang1,2, Nan Zhang1, Yarong Xu1

  • 1School of Natural and Applied Science, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.

Macromolecular Rapid Communications
|May 22, 2019
PubMed
Summary
This summary is machine-generated.

Molecular imprinting creates polymer cavities that mimic biological recognition for selective separation and analysis. This review covers materials and strategies for imprinting small molecules, large molecules, and cells.

Keywords:
biological templatesmolecular imprintingmolecularly imprinted materialsselective recognition

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Area of Science:

  • Materials Science
  • Biochemistry
  • Analytical Chemistry

Background:

  • Molecular imprinting (MIMs) creates synthetic receptors with shape and chemical memory, mimicking biological recognition like antigen-antibody interactions.
  • MIMs offer high selectivity and predictable structures, driving research in separation, recognition, and regeneration of biological targets.

Purpose of the Study:

  • To review carrier materials (hydrogels, porous materials, nanoparticles, 2D materials) used in molecular imprinting.
  • To discuss imprinting strategies for various biological templates, from small molecules to cells.
  • To highlight differences and connections between small, large, and cell imprinting techniques.

Main Methods:

  • Review of current literature on molecular imprinting materials and strategies.
  • Analysis of carrier material characteristics and morphologies.
  • Case studies illustrating imprinting techniques for diverse biological templates.

Main Results:

  • Discussion on the role of hydrogels, porous materials, nanoparticles, and 2D materials in molecular imprinting.
  • Detailed comparison of bulk, surface, interfacial, and cell imprinting strategies.
  • Emphasis on the adaptability of MIMs for different molecular scales.

Conclusions:

  • Molecular imprinting provides versatile biomimetic receptors for biological applications.
  • Carrier materials and imprinting strategies are crucial for effective separation and recognition.
  • Future research directions in molecular imprinting are outlined.