Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Empirical paternity exclusion rates.

D W Gjertson, M R Mickey, P I Terasaki

    The American Journal of Forensic Medicine and Pathology
    |June 1, 1987
    PubMed
    Summary

    A new empirical method simplifies paternity exclusion rate estimation for genetic systems. This approach offers advantages over traditional formulas, especially for complex genetic data, and reveals higher Human Leukocyte Antigen (HLA) exclusion rates across racial groups.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Paul I. Terasaki, PhD, 1929-2016.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
    Same author

    rPSGL-Ig for improvement of early liver allograft function: a double-blind, placebo-controlled, single-center phase II study.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
    Same author

    SEROTYPING FOR HOMOTRANSPLANTATION. VII. SELECTION OF KIDNEY DONORS FOR THIRTY-TWO RECIPIENTS.

    Annals of the New York Academy of Sciences·2010
    Same author

    A computer-aided diagnosis system for quantitative scoring of extent of lung fibrosis in scleroderma patients.

    Clinical and experimental rheumatology·2010
    Same author

    Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.

    Genes and immunity·2008
    Same author

    Phosphorylated S6 ribosomal protein: a novel biomarker of antibody-mediated rejection in heart allografts.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2006

    Area of Science:

    • Forensic Genetics
    • Population Genetics
    • Statistical Genetics

    Background:

    • Traditional methods for estimating paternity exclusion rates often involve complex calculations.
    • Existing formulas can be computationally intensive and may require difficult-to-measure parameters like gametic disequilibrium.
    • There is a need for more accessible and efficient methods for paternity testing in diverse populations.

    Purpose of the Study:

    • To develop and validate an empirical method for estimating paternity exclusion rates.
    • To compare the efficiency and accuracy of the new method against traditional formula-based approaches.
    • To report paternity exclusion rates for specific genetic systems across different racial groups.

    Main Methods:

    • An empirical method was developed by analyzing fictitious 'nonfather' cases derived from actual paternity disputes.

    Related Experiment Videos

  • This technique involves data file manipulation rather than complex mathematical computations.
  • Exclusion rates were calculated for standard and one-parent paternity cases using four genetic systems (HLA, ABO, MNSs, Rh) in three racial groups (Caucasians, blacks, Hispanics).

    • Main Results:

    • The empirical method proved simpler and avoided the need for measuring parameters like recombination fraction.
    • Higher Human Leukocyte Antigen (HLA) exclusion rates were observed: 93.25% for Caucasians, 94.62% for blacks, and 95.82% for Hispanics.
    • High combined exclusion rates were found for one-parent paternity cases: 89.59% for Caucasians, 91.65% for blacks, and 92.54% for Hispanics.

    Conclusions:

    • The developed empirical method provides a practical and advantageous alternative for estimating paternity exclusion rates.
    • The findings highlight the effectiveness of the new method, particularly for multiallele, multiloci genetic systems.
    • The study provides valuable updated exclusion rate data for forensic and paternity testing applications.