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Related Experiment Videos

Does oral enzyme replacement therapy reverse intestinal lactose malabsorption?

M Moskovitz, C Curtis, J Gavaler

    The American Journal of Gastroenterology
    |July 1, 1987
    PubMed
    Summary
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    Oral enzyme replacement therapy using beta-D-galactosidase (Lactrase) can improve symptoms and reduce breath hydrogen excretion in some lactase-deficient patients, especially at higher doses.

    Area of Science:

    • Gastroenterology
    • Nutritional Science
    • Enzymology

    Background:

    • Lactose intolerance is a common condition characterized by the inability to digest lactose, leading to gastrointestinal distress.
    • Lactase deficiency results in malabsorption of lactose, causing symptoms like bloating, gas, and diarrhea after milk consumption.

    Purpose of the Study:

    • To evaluate the efficacy of oral enzyme replacement therapy with beta-D-galactosidase (Lactrase) in managing symptoms and breath hydrogen excretion in lactase-deficient individuals.
    • To determine the optimal dosage of Lactrase for alleviating lactose malabsorption.

    Main Methods:

    • A study involving 16 symptomatic lactase-deficient patients who underwent hydrogen breath tests after consuming whole milk.
    • Patients were administered varying doses of Lactrase (250 mg and 500 mg) to assess its impact on breath hydrogen levels and symptom severity.

    Related Experiment Videos

  • Comparison of breath hydrogen excretion and symptom scores between baseline (milk alone) and Lactrase treatment groups.

    • Main Results:

    • A significant reduction in cumulative and peak hydrogen excretion was observed with a 500 mg dose of Lactrase compared to baseline (p ≤ 0.05).
    • 31% of patients normalized hydrogen excretion with 250 mg Lactrase, and an additional 57% normalized with 500 mg.
    • While 56% of patients with normalized hydrogen excretion became asymptomatic, some patients also reported symptom relief without complete normalization of hydrogen levels.

    Conclusions:

    • Oral Lactrase, particularly at a sufficient dosage, can temporarily reverse lactose malabsorption in some lactase-deficient patients.
    • Enzyme replacement therapy offers a potential strategy for managing symptoms associated with lactose intolerance.