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Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis

Rafal Tokarz1, Jeffrey S Hyams2, David R Mack3

  • 1Center for Infection and Immunity, Mailman School of Public Health, Columbia University, NY, USA.

Inflammatory Bowel Diseases
|May 22, 2019
PubMed

Insights

This study found no link between viral infections and the onset of pediatric ulcerative colitis (UC). Virus presence in stool did not correlate with UC development or disease severity in children.

Area of Science:

  • Gastroenterology
  • Virology
  • Pediatric Health

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • Viral infections are hypothesized as potential triggers for UC onset.

Purpose of the Study:

  • To investigate the association between viral infections and the onset of pediatric ulcerative colitis (UC).
  • To analyze the stool virome in children with newly diagnosed UC using high-throughput sequencing.

Main Methods:

  • Employed VirCapSeq-Vert, a high-throughput sequencing virus capture platform.
  • Examined stool samples from children with moderate to severe UC at presentation and after remission.
  • Included a control group of children diagnosed with irritable bowel syndrome.

Main Results:

  • A wide range of animal viruses were detected, belonging to 12 viral families.
  • Viruses were present in 50% of UC samples at presentation and 40% of control samples.
  • The UC cohort showed a higher prevalence of anelloviruses, but no single virus was linked to UC onset or severity.

Conclusions:

  • The presence of viruses in stool is not associated with the onset of pediatric ulcerative colitis.
  • No specific virus was identified as a causative agent for UC in children.
Abstract

Keywords:
childrenulcerative colitisvirome

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