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Updated: Jan 24, 2026

An Epithelial Abrasion Model for Studying Corneal Wound Healing
Published on: December 29, 2021
Anti-inflammatory and wound healing effects of gel containing Kaempferia marginata extract
Thawiwan Muthachan1, Supinya Tewtrakul2
1Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla Univesity, Hat-Yai, Songkhla, 90112, Thailand; Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand.
Ethnopharmacological Relevance:
Kaempferia marginata Carey (Zingiberaceae family) has been traditionally used in the treatment of inflammation. The whole plant decoction is used for treatment of fever. Ethanol extracts which exert potent anti-inflammatory properties are selected for wound healing assay.
Aim Of The Study:
This study aimed to investigate activities of the extract and gel formulation on anti-inflammatory and wound healing activities. The anti-inflammatory and wound healing properties from this plant could support its traditional uses and obtain a new pharmaceutical product with good physical, chemical and biological stabilities.
Materials And Methods:
The anti-inflammatory activity was tested on anti-nitric oxide (NO) production using RAW264.7 cells and wound healing assay using human dermal fibroblast (HDF) cells.
Results:
The results found that the anti-inflammatory activity of gel containing K. marginata at 10% w/w showed the highest activity with an IC50 value of 12.50 μg/ml (Diclofenac gel, IC50 value = 64.90 μg/ml). It also revealed that wound healing activities of K. marginata gel (5% w/w) showed the highest % cell viability (134.05%) and the highest % cell migration at 85.20 using HDF cells.
Conclusion:
The present study shows that gel containing K. marginata extracts have good anti-inflammatory and wound healing properties in vitro.
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