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Inducible macrolides-lincosamides-streptogramin B resistance in Bacteroides species

M Reig, M G Campello, F Baquero

    Antimicrobial Agents and Chemotherapy
    |April 1, 1987
    PubMed

    Insights

    Inducible macrolides-lincosamides-streptogramin B resistance is now evident in Bacteroides species. Erythromycin resistance in these bacteria was found to correlate with reduced susceptibility to clindamycin.

    Area of Science:

    • Microbiology
    • Antimicrobial Resistance
    • Bacteriology

    Background:

    • Macrolides-lincosamides-streptogramin B (MLSB) resistance is a growing concern in clinical settings.
    • Bacteroides species are common commensals but can be opportunistic pathogens.
    • Understanding resistance mechanisms in Bacteroides is crucial for effective treatment.

    Purpose of the Study:

    • To investigate the presence and characteristics of inducible MLSB resistance in Bacteroides species.
    • To determine the relationship between erythromycin resistance and clindamycin susceptibility in Bacteroides.

    Main Methods:

    • Phenotypic testing of Bacteroides isolates for antimicrobial susceptibility.
    • Induction of resistance using different macrolide agents.
    • Analysis of 144 Bacteroides isolates for resistance patterns.

    Main Results:

    • The study provides the first evidence of inducible MLSB resistance in Bacteroides species.
    • Exposure to various macrolides induced clindamycin resistance in a previously susceptible Bacteroides vulgatus strain.
    • A significant association was observed between erythromycin resistance and decreased clindamycin susceptibility across 144 isolates.

    Conclusions:

    • Inducible MLSB resistance mechanisms are present in Bacteroides species.
    • Erythromycin resistance may serve as an indicator for potential clindamycin resistance in Bacteroides.
    • These findings highlight the need for careful antimicrobial stewardship when treating infections caused by Bacteroides.

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