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Rescue Therapy for Genotype-3 DAA Non-responders, Almost all Done
Susana Llerena1, Joaquín Cabezas1, Antonio Cuadrado1
1Gastroenterology and Hepatology Department, Hospital Universitario Marques de Valdecilla, Santander, Spain; Infection, Immunity and Digestive Disease Group, Instituto de Investigation Valdecilla (IDIVAL), Santander, Spain.
Abstract:
Nowadays, the retreatment of patients with Hepatitis C virus (HCV) genotype 3 (GT3) especially cirrhotic, who have already been treated with regimens containing a NS5A inhibitor represents a challenge. Use a novel retreatment option for patients with a difficult approach. We present three case reports of retreatment with a new combination of Direct-acting antivirals (DAAs), Sofosbuvir, Elbasvir/Grazoprevir in patients with GT3 with a previous failure with Sofosbuvir/Ledipasvir. All the cases achieved sustained virologic response (SVR) at week +12 without adverse effects. In our experience, this combo may represent an effective and safe option for these patients.
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