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HLA Class II-DRB1 Alleles with Hepatitis C Virus Infection Outcome in Egypt: A Multicentre Family-based Study

Mahmoud El-Bendary1, Mustafa Neamatallah2, Hatem Elalfy1

  • 1Tropical Medicine & Hepatology, Mansoura Faculty Of Medicine, Mansoura University, Mansoura,Dakahlyia, Egypt.

Annals of Hepatology
|May 23, 2019
PubMed

Insights

Certain HLA-DRB1 alleles increase Hepatitis C virus (HCV) susceptibility in Egyptian families, while others offer protection. This study identifies specific alleles linked to chronic HCV infection risk and spontaneous viral clearance.

Area of Science:

  • Immunogenetics
  • Hepatology
  • Virology

Background:

  • Hepatitis C virus (HCV) infection poses a significant global health challenge.
  • Human Leukocyte Antigen (HLA) -DRB1 alleles play a crucial role in modulating immune responses to HCV.
  • Understanding the genetic predisposition to HCV infection is vital for developing effective prevention and treatment strategies.

Purpose of the Study:

  • To investigate the association between specific HLA-DRB1 alleles and susceptibility to chronic Hepatitis C virus (CHC) infection.
  • To identify HLA-DRB1 alleles that may confer protection against HCV infection or promote spontaneous viral clearance (SVC).
  • To clarify the contribution of HLA-DRB1 alleles in HCV infection within a multicentre, family-based study in Egypt.

Main Methods:

  • A multicentre family-based study involving 162 Egyptian families (951 individuals).
  • Categorization of individuals into three groups: chronic hepatitis C (CHC), control (household contact -ve to HCV), and spontaneously cleared virus (SVC).
  • Genotyping of HLA-DRB1 alleles using Sequence Specific Primed Polymerase Chain Reaction (SSP-PCR) and Sequence Based Typing (SBT).

Main Results:

  • HLA-DRB1*030101 and HLA-DRB1*130101 alleles showed a highly significant association with chronic hepatitis C (CHC) in Egyptian families.
  • These risk alleles (DRB1*030101 and DRB1*130101) were significantly more frequent in CHC patients compared to control and spontaneously cleared virus (SVC) groups.
  • Conversely, alleles DRB1*040101, DRB1*040501, DRB1*7:01:01, and DRB1*110101 were more prevalent in the SVC group, suggesting a protective role against HCV infection.

Conclusions:

  • HLA-DRB1*030101 and DRB1*130101 alleles are associated with an increased risk of developing chronic Hepatitis C virus (HCV) infection among Egyptian families.
  • HLA-DRB1*040101, DRB1*040501, DRB1*7:01:01, and DRB1*110101 alleles appear to confer protection against HCV infection, potentially promoting spontaneous viral clearance.
  • These findings highlight the significant role of specific HLA-DRB1 alleles in determining individual susceptibility and resistance to Hepatitis C virus infection.
Abstract

Keywords:
HCV susceptibilityHLA-DRB1 polymorphismintrafamilialvirus clearance

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