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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.5K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.5K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.4K

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Related Experiment Video

Updated: Jan 24, 2026

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry
11:39

Extraction of Aqueous Metabolites from Cultured Adherent Cells for Metabolomic Analysis by Capillary Electrophoresis-Mass Spectrometry

Published on: June 9, 2019

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A NOTCH added to metabolomics.

Odd Terje Brustugun1

  • 1Section of Oncology, Drammen Hospital, Vestre Viken Health Trust, Dronninggata 28, N-3004, Drammen, Norway. otr@vestreviken.no.

British Journal of Cancer
|May 23, 2019
PubMed
Summary
This summary is machine-generated.

Cancer cells exhibit altered metabolism. This study analyzes metabolism data to understand cancer

Area of Science:

  • Oncology
  • Cancer Metabolism
  • Transcriptomics

Background:

  • Altered cellular metabolism is a key characteristic of cancer.
  • Metabolic reprogramming is increasingly recognized as a potential therapeutic target in oncology.

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