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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
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Evaluation of treatment options for methicillin-resistant Staphylococcus aureus infections in the obese patient

Navaneeth Narayanan1,2, Christopher D Adams1, David W Kubiak3

  • 1Department of Pharmacy Practice, Rutgers University, Ernest Mario School of Pharmacy, Piscataway, NJ, USA.

Infection and Drug Resistance
|May 23, 2019
PubMed

Insights

Obese patients with methicillin-resistant Staphylococcus aureus (MRSA) infections require careful antibiotic selection. This review summarizes key pharmacokinetic and pharmacodynamic factors for effective MRSA treatment in obesity.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Obesity Medicine

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in both healthcare and community settings.
  • Obesity is a growing global health concern and a recognized risk factor for infections.
  • Treating MRSA in obese patients presents challenges due to limited data on optimal antibiotic strategies.

Purpose of the Study:

  • To review the pharmacokinetic and pharmacodynamic considerations for antibiotic therapy in obese patients with MRSA infections.
  • To guide clinicians in selecting appropriate antibiotic choices and dosing for this patient population.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of physiological changes in obesity affecting drug disposition.
  • Evaluation of pharmacokinetic and pharmacodynamic data relevant to MRSA treatment.

Main Results:

  • Obesity alters drug biodistribution, elimination, and absorption, impacting pharmacokinetic parameters.
  • Specific data on optimal antibiotic selection and dosing for MRSA in obese individuals is scarce.
  • Understanding these altered parameters is crucial for effective treatment.

Conclusions:

  • Tailoring antibiotic therapy based on pharmacokinetic and pharmacodynamic principles is essential for treating MRSA infections in obese patients.
  • Further research is needed to establish evidence-based guidelines for MRSA treatment in this population.
Keywords:
antibioticsmethicillin-resistant Staphylococcus aureusobesitypharmacokinetics

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