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Diagnostic Accuracy of a MR Protocol Acquired with and without Endorectal Coil for Detection of Prostate Cancer: A
Borna K Barth1, Niels J Rupp2, Alexander Cornelius3
1Institute of Diagnostic and Interventional Radiology, Zurich.
Introduction:
The purpose of this study was to compare diagnostic accuracy of a prostate multiparametric magnetic resonance imaging (mpMRI) protocol for detection of prostate cancer between images acquired with and without en-dorectal coil (ERC).
Materials:
This study was approved by the regional ethics committee. Between 2014 and 2015, 33 patients (median age 51.3 years; range 42.1-77.3 years) who underwent prostate-MRI at 3T scanners at 2 different institutions, acquired with (mpMRIERC) and without (mpMRIPPA) ERC and who received radical prostatectomy, were included in this retrospective study. Two expert readers (R1, R2) attributed a PI-RADS version 2 score for the most suspect (i. e. index) lesion for mpMRIPPA and mpMRIERC. Sensitivity and positive predictive value for detection of index lesions were assessed using 2 × 2 contingency tables. Differences between groups were tested using the McNemar test. Whole-mount histopathology served as reference standard.
Results:
On a quadrant-basis cumulative sensitivity ranged between 0.61-0.67 and 0.76-0.88 for mpMRIPPA and mpMRIERC protocols, respectively (p > 0.05). Cumulative positive predictive value ranged between 0.80-0.81 and 0.89-0.91 for mpMRIPPA and mpMRIERC protocols, respectively. The differences were not statistically significant for R1 (p = 0.267) or R2 (p = 0.508).
Conclusion:
Our results suggest that there may be no significant differences for detection of prostate cancer between images acquired with and without an ERC.
Insights
Comparing prostate cancer detection using MRI with and without an endorectal coil (ERC) showed no significant diagnostic accuracy differences. Both multiparametric MRI (mpMRI) protocols demonstrated comparable sensitivity and positive predictive value for identifying index lesions.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Prostate cancer detection relies on accurate imaging.
- Multiparametric magnetic resonance imaging (mpMRI) is a key tool.
- The utility of an endorectal coil (ERC) in prostate mpMRI protocols requires evaluation.
Purpose of the Study:
- To compare the diagnostic accuracy of prostate cancer detection using mpMRI with and without an ERC.
- To evaluate sensitivity and positive predictive value of mpMRI protocols with and without ERC.
Main Methods:
- Retrospective study of 33 patients who underwent 3T prostate-MRI.
- Images acquired with (mpMRI_ERC) and without (mpMRI_PPA) ERC were analyzed.
- Two expert readers assigned PI-RADS v2 scores; sensitivity and PPV assessed against histopathology.
Main Results:
- Cumulative sensitivity ranged from 0.61-0.67 for mpMRI_PPA and 0.76-0.88 for mpMRI_ERC.
- Cumulative positive predictive value ranged from 0.80-0.81 for mpMRI_PPA and 0.89-0.91 for mpMRI_ERC.
- No statistically significant differences were found between the two protocols for either reader.
Conclusions:
- The study suggests no significant difference in prostate cancer detection between mpMRI with and without an ERC.
- Both imaging protocols demonstrated comparable performance in identifying index lesions.
- Further research may be warranted to confirm these findings in larger cohorts.
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