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Increasing Epstein-Barr virus infection in Chinese children: A single institutional based retrospective study

Kiran Devkota1, Maio He1, Meng Yi Liu1

  • 1Department of Pediatrics, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 44200, China.

F1000Research
|May 25, 2019
PubMed

Insights

Epstein-Barr virus (EBV) hospital admissions are increasing in children. Infants under 4 years are most susceptible, with the highest risk group being those aged 6 months to 1 year.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Epstein-Barr virus (EBV) is a common human herpesvirus and the primary cause of infectious mononucleosis.
  • EBV primary infections are increasing in some regions, particularly affecting young children.
  • Clinical manifestations in children can be severe and involve multiple organ systems.

Purpose of the Study:

  • To estimate the overall prevalence of EBV infection in pediatric patients.
  • To identify the high-risk age groups for EBV infection among children.
  • To analyze trends in EBV hospital admissions over a four-year period.

Main Methods:

  • A retrospective study of 253 pediatric patients under 15 years with EBV DNA-positive serum PCR results.
  • Data collected from Renmin Hospital (Shiyan, China) between 2014 and 2017.
  • Patients categorized into age groups: 0-<4 years, 4-<6 years, and 6-<15 years.

Main Results:

  • Yearly EBV prevalence per 1000 admissions increased from 4.99 (2014) to 12.16 (2017).
  • Children under 4 years accounted for the highest infection rate (74.7%).
  • The highest risk group identified was children aged 6 months to 1 year.

Conclusions:

  • Hospital admissions for pediatric EBV infections are on the rise.
  • Children under 4 years exhibit high susceptibility to EBV.
  • Infants aged 6 months to 1 year represent the most vulnerable demographic for EBV infection.

Keywords:
Infectious mononucleosis; Prevalence; EBV DNA; Epstein–Barr virus

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