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Acquired Long QT Syndrome and Electrophysiology of Torsade de Pointes

Nabil El-Sherif1,2, Gioia Turitto3, Mohamed Boutjdir1,2,4

  • 1SUNY Downstate Medical Center NY, US.

Arrhythmia & Electrophysiology Review
|May 23, 2019
PubMed

Insights

Acquired long QT syndrome (LQTS), often overlooked, affects more patients than congenital LQTS. This review details acquired LQTS mechanisms, diagnosis, and management, including torsade de pointes.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Pharmacology

Background:

  • Congenital long QT syndrome (LQTS) is a well-studied cardiac ion channelopathy.
  • Acquired LQTS is more prevalent and managed by a broader range of healthcare professionals.
  • Understanding acquired LQTS is crucial for therapeutic decision-making.

Purpose of the Study:

  • To review the electrophysiological mechanisms of acquired LQTS.
  • To outline the ECG characteristics, clinical presentation, and management strategies for acquired LQTS.
  • To provide a comprehensive overview of the electrophysiological mechanisms underlying torsade de pointes.

Main Methods:

  • Literature review focusing on acquired LQTS and torsade de pointes.
  • Analysis of electrophysiological mechanisms, clinical manifestations, and treatment approaches.
  • Synthesis of information on ECG findings and patient management.

Main Results:

  • Acquired LQTS arises from various factors, distinct from congenital forms.
  • Specific ECG patterns and clinical symptoms are associated with acquired LQTS.
  • Effective management strategies exist for acquired LQTS and associated arrhythmias.

Conclusions:

  • Acquired LQTS requires careful consideration in clinical practice due to its frequency.
  • A thorough understanding of its mechanisms and management is essential for physicians.
  • This review provides a comprehensive resource on acquired LQTS and torsade de pointes.

Keywords:
Long QT syndromeelectrophysiologytorsade de pointes

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