L-type voltage-gated calcium channels in stem cells and tissue engineering
Yi-Zhou Tan1, Dong-Dong Fei1,2, Xiao-Ning He2
1Department of Periodontology, State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, School of Stomatology, The Fourth Military Medical University, Xi'an, China.
Cell Proliferation
|May 23, 2019
Summary
L-type voltage-gated calcium channels (L-VGCCs) are crucial for stem cell proliferation and differentiation. This review explores their role in mesenchymal stem cells (MSCs) and neural stem cells (NSCs), highlighting therapeutic potential.
Area of Science:
- Cell Biology
- Stem Cell Research
- Ion Channel Physiology
Background:
- L-type voltage-gated calcium channels (L-VGCCs) are vital for intracellular signaling in excitable cells.
- Emerging research indicates L-VGCCs play roles in non-excitable cells, including stem cells.
- A systematic review on L-VGCCs in stem cells is lacking.
Purpose of the Study:
- To systematically review the involvement of L-VGCCs in stem cell functions.
- To focus on L-VGCCs' role in osteogenesis by mesenchymal stem cells (MSCs).
- To examine L-VGCCs' role in neurogenesis by neural stem/progenitor cells (NSCs).
Main Methods:
- Literature review of studies investigating L-VGCCs in stem cells.
- Analysis of L-VGCC involvement in MSC osteogenesis.
- Evaluation of L-VGCCs' contribution to NSC neurogenesis.
Main Results:
- L-VGCCs are implicated in the proliferation and differentiation of various stem cell types.
- Evidence suggests L-VGCCs modulate osteogenic differentiation in MSCs.
- L-VGCCs are involved in the neurogenic differentiation of NSCs.
Conclusions:
- L-VGCCs are significant regulators of stem cell behavior, particularly in osteogenesis and neurogenesis.
- Targeting L-VGCCs presents a promising strategy for tissue engineering and regenerative medicine.
- Further research into L-VGCCs could unlock new therapeutic avenues for tissue repair.
Keywords:
L-type voltage-gated calcium ion channelsmyogenesisneurogenesisosteogenesisstem cellstissue engineeringMore Related Videos
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