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Development of High-Strength Extended-Release Multiparticulate System by Crystallo-co-agglomeration Technique with
Vinod L Gaikwad1, Namdeo R Jadhav2, Atmaram P Pawar3
1Department of Pharmaceutics, BVDU Poona College of Pharmacy, Pune, Maharashtra State, 411038, India. vinod_gaikwad29@yahoo.com.
AAPS Pharmscitech
|May 23, 2019
Summary
This study developed directly compressible, high-strength extended-release spherical agglomerates of indapamide using a novel crystallo-co-agglomeration technique, simplifying tablet preparation and improving drug delivery.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Traditional tablet preparation involves numerous steps, increasing the risk of critical quality attribute deviations.
- Developing robust formulations with controlled release properties is crucial for effective drug delivery.
Purpose of the Study:
- To develop directly compressible, high-strength extended-release spherical agglomerates of indapamide using crystallo-co-agglomeration.
- To investigate the influence of polymers (hydroxypropyl methylcellulose, polyethylene glycol, ethyl cellulose) on agglomerate properties and drug release.
Main Methods:
- Utilized crystallo-co-agglomeration technique to prepare indapamide-talc agglomerates.
- Employed a rotatable central composite design to optimize polymer concentrations.
- Evaluated agglomerates for morphological, micromeritic, mechanical, and in vitro drug release characteristics.
Main Results:
- Achieved high yield (>97%) with excellent crushing strength and low friability, indicating good handling properties.
- Spectroscopic and X-ray diffraction studies confirmed drug-polymer compatibility and reduced indapamide crystallinity.
- Controlled drug release up to 6 hours was achieved, attributed to miniscular dosage form and talc hydrophobicity.
Conclusions:
- The crystallo-co-agglomeration technique is effective for producing directly compressible, high-strength extended-release indapamide agglomerates.
- This method offers a simplified approach to tablet manufacturing with improved formulation quality and predictable drug release.
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