Dynamic, patient-specific mitral valve modelling for planning transcatheter repairs

Area of Science:

• Cardiovascular Research
• Biomedical Engineering
• Medical Simulation

Background:

• Transcatheter mitral valve repair is advancing rapidly.
• Simulating mitral valve repair outcomes is challenging due to complex geometry and hemodynamics.

Purpose of the Study:

• To develop a workflow for manufacturing dynamic, patient-specific mitral valve models.
• To enable simulation of mitral valves for transcatheter repair applications.

Main Methods:

• Utilized transesophageal echocardiography to generate dynamic physical replicas of patient valves.
• Employed a dynamic pulse duplicator to simulate realistic hemodynamic conditions.
• Validated the workflow with six patient datasets featuring unique pathologies.

Main Results:

• The workflow demonstrated excellent anatomical accuracy in replicating patient valves.
• Models successfully replicated mitral valve regurgitation pathologies.
• Statistical analysis showed no significant difference between patient and model measurements, indicating high fidelity.

Conclusions:

• The developed workflow offers a promising technology for simulating mitral valve morphology.
• Combines dynamic environments with patient-specific modeling for transcatheter repair simulation.