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A Calcium Phosphate-Induced Mouse Abdominal Aortic Aneurysm Model
Published on: November 18, 2022
Health gains, costs and cost-effectiveness of a population-based screening programme for abdominal aortic aneurysms
N Nair1, G Kvizhinadze1, G T Jones2
1Burden of Disease Epidemiology, Equity and Cost-Effectiveness Programme (BODE3), Department of Public Health, University of Otago, Wellington, New Zealand.
Insights
Implementing a UK-style abdominal aortic aneurysm (AAA) screening program in New Zealand is cost-effective. This approach offers significant health gains, making it a valuable public health strategy for older men.
Area of Science:
- Public Health
- Health Economics
- Vascular Surgery
Background:
- Abdominal aortic aneurysm (AAA) rupture has a high fatality rate.
- Population-based AAA screening in older men, like in the UK and Sweden, reduces mortality.
- New Zealand currently lacks a national AAA screening program.
Purpose of the Study:
- To assess the cost-effectiveness of a UK-style AAA screening program within the New Zealand healthcare system.
- To evaluate the potential health gains and costs associated with implementing such a program.
Main Methods:
- A cost-utility analysis was conducted using a Markov macrosimulation model.
- The model was adapted with New Zealand-specific data to estimate quality-adjusted life-years (QALYs) and costs.
- A lifetime horizon and a health system perspective were adopted for the analysis.
Main Results:
- The estimated cost per QALY gained was NZ$15,300 (95% UI: NZ$8,700–$31,000).
- The program is projected to yield 117 QALYs (95% UI: 53–212) with total health system costs of NZ$1.68 million (95% UI: NZ$820,200–$3.24 million).
Conclusions:
- A UK-style AAA screening program is projected to be cost-effective in New Zealand.
- The cost per QALY gained falls below New Zealand's GDP per capita threshold, supporting its implementation.
Background:
Abdominal aortic aneurysm (AAA) rupture carries a high fatality rate. AAAs can be detected before rupture by abdominal ultrasound imaging, allowing elective repair. Population-based screening for AAA in older men reduces AAA-related mortality by about 40 per cent. The UK began an AAA screening programme offering one-off scans to men aged 65 years in 2009. Sweden has a similar programme. Currently, there is no AAA screening programme in New Zealand. This cost-utility analysis aimed to assess the cost-effectiveness of a UK-style screening programme in the New Zealand setting.
Methods:
The analysis compared a formal AAA screening programme (one-off abdominal ultrasound imaging for about 20 000 men aged 65 years in 2011) with no systematic screening. A Markov macrosimulation model was adapted to estimate the health gains (in quality-adjusted life-years, QALYs), health system costs and cost-effectiveness in New Zealand. A health system perspective and lifetime horizon was adopted.
Results:
With New Zealand-specific inputs, the adapted model produced an estimate of about NZ $15 300 (€7746) per QALY gained, with a 95 per cent uncertainty interval (UI) of NZ $8700 to 31 000 (€4405 to 15 694) per QALY gained. Health gains were estimated at 117 (95 per cent UI 53 to 212) QALYs. Health system costs were NZ $1·68 million (€850 535), with a 95 per cent UI of NZ $820 200 to 3·24 million (€415 243 to €1·65 million).
Conclusion:
Using New Zealand's gross domestic product per capita (about NZ $45 000 or €22 100) as a cost-effectiveness threshold, a UK-style AAA screening programme would be cost-effective in New Zealand.
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