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Topical scabies therapy with permethrin is effective and well tolerated in infants younger than two months

Johanna Charlotte Hoffmann1, Rotraut Mößner1, Michael Peter Schön1

  • 1Department of Dermatology, Venerology und Allergology, Medical Center of University Goettingen, Goettingen, Germany.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|May 23, 2019
PubMed

Insights

Topical permethrin 5% cream is safe for treating infantile scabies in infants under two months old. This study found the treatment well-tolerated, even with repeated applications, supporting its use in this vulnerable population.

Area of Science:

  • Dermatology
  • Pediatrics
  • Parasitology

Background:

  • Infantile scabies requires prompt management to prevent disease spread.
  • Limited data exists on topical permethrin 5% cream for infants under two months.
  • Current use of permethrin cream in this age group is off-label.

Purpose of the Study:

  • To evaluate the safety and efficacy of topical permethrin 5% cream.
  • To assess treatment outcomes in infants younger than two months with scabies.

Main Methods:

  • Retrospective analysis of seven infants under two months diagnosed with scabies.
  • Diagnosis confirmed via clinical symptoms and dermoscopy.
  • Evaluation of permethrin 5% cream efficacy and safety.

Main Results:

  • Permethrin 5% cream was administered to seven infants.
  • Four patients required repeat applications (up to three times) due to incomplete resolution or recurrence.
  • The treatment was well-tolerated by all infants.

Conclusions:

  • Topical permethrin 5% cream is safe for infants younger than two months.
  • The treatment is effective, although repeat applications may be necessary.
  • Confirms the safety of permethrin 5% cream for this pediatric age group.
Abstract

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