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An evidence-based model to consolidate medication adherence cost estimation: the medication adherence cost estimation
Rachelle L Cutler1, Naomi Van der Linden2, Shalom I Charlie Benrimoj3
1Graduate School of Health, University of Technology Sydney, Sydney, Australia, 2007.
Journal of Comparative Effectiveness Research
|May 23, 2019
Summary
Developing a standardized framework for medication nonadherence costs helps compare studies. This framework supports evidence-based health policy decisions by using consistent terminology for medication adherence economic impact.
Area of Science:
- Health Economics
- Pharmacoeconomics
- Health Policy Research
Background:
- Medication nonadherence presents a significant economic burden.
- Existing studies on the cost of nonadherence lack standardization.
- A consistent framework is needed for accurate economic impact assessment.
Purpose of the Study:
- To establish a standardized framework for evaluating the economic impact of medication nonadherence.
- To aggregate and analyze cost outcome indicators from existing literature.
- To facilitate comparative analysis of medication adherence cost studies.
Main Methods:
- Secondary analysis of published literature reporting cost data.
- Aggregation of cost outcome indicators.
- Weighted-average cost analysis to determine cost contributions.
Main Results:
- Direct costs were reported in 92% of studies, indirect costs in 4%.
- Hospital (68%), pharmacy (72%), and primary care (18%) were key cost categories.
- Average unadjusted direct costs ranged from $625-$154,203 (88% of total); adjusted medical costs $565-$56,313 (96% of total).
Conclusions:
- The developed framework standardizes medication adherence cost estimation.
- It enables comparison across different costing studies.
- Facilitates informed health policy decisions through consistent evidence and terminology.
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